학술논문
Efficacy of Intrathecal Isoniazid and Steroid Therapy in Refractory Tuberculous Meningitis
Document Type
Journal Article
Author
Akitsugu Furumoto; Atsushi Nagaoka; Ayumi Fujita; Hiroshi Mukae; Katsunori Yanagihara; Kazuaki Takeda; Kazuko Yamamoto; Kenta Ujifuku; Koichi Izumikawa; Koji Ishii; Masato Tashiro; Naoki Iwanaga; Nobuyuki Ashizawa; Ryotaro Kubo; Ryuta Tagawa; Shotaro Ide; Shunsuke Yoshimura; Takahiro Takazono; Takeshi Tanaka; Tomohiro Koga; Yuya Ito
Source
Internal Medicine. :1917-23
Subject
Language
English
ISSN
0918-2918
1349-7235
1349-7235
Abstract
Tuberculous meningitis is an infectious disease with high mortality. Literature describing intrathecal therapy for tuberculous meningitis is scarce. We herein report a case of refractory tuberculous meningitis in a 52-year-old woman with underlying neuropsychiatric systemic lupus erythematosus. Despite systemic treatment with anti-tuberculosis drugs and dexamethasone, her meningeal irritation deteriorated. Intrathecal isoniazid and prednisolone administration was therefore initiated, and the symptoms of severe meningeal irritation improved along with head magnetic resonance imaging and cerebrospinal fluid findings. This case report highlights the efficacy of intrathecal isoniazid and steroid injections for refractory tuberculous meningitis, particularly in patients with severe meningeal irritation.