부산대학교 도서관

Between 1979 and 1997, 56 patients with previously untreated locally advanced squamous cell carcinoma of the tongue were treated in our hospital. Thirty patients of them were received surgery alone. Since the microvascular reconstruction started in 1987, no patients with unresectable primary lesion have appeared. The overall 5-year survival rate of 46 patients treated since 1987 was 51%, although the rate of 10 patients before 1986 was 30%. The 5-year survival rates by pN stage were 90% in pN0 (19 cases), 67% in pN1 (6 cases), 0% in pN2a (1 case), 14% in pN2b (14cases), 0% in pN2c (6 cases), respectively. The cases of pN0 and pN1 were better in prognosis than pN2 cases significantly (p<0.0001). The 5-year survival rate of 12 patients received preoperative chemotherapy was 42%, although the rate of 34 patients without preoperative chemotherapy was 54%. It demonstrated no benefit in survival using preoperative chemotherapy. It was suggested that irradiation was necessary to decrease the recurrence rate of the neck in pN2 cases, because pN stage was prognostic factor in locally advanced lingual cancer.