학술논문
Comparative Study on Sultamicillin and Bacampicillin in the Treatment of Respiratory Tract Infections / 呼吸器感染症に対するSultamicillinとBacampicillinの薬効比較試験
Document Type
Journal Article
Author
Akira IKEBE; Akira KAGIOKA; Akira SAITO; Akira UJIIE; Asako YAMAMOTO; Atsushi SAITO; Atsushi SHINODA; Atsuyuki KURASHIMA; Eiji INOUE; Fukuo IIJIMA; Fumio MIKI; Fumiyuki KUZE; Fusanosuke YAMASAKU; Hajime TAKEDA; Hidekazu HANAKI; Hideki NISHIYAMA; Hideo IKEMOTO; Hideo SASAKI; Hirofumi FUKUHARA; Hiroichi TANIMOTO; Hiroshi OKUBO; Hiroyoshi ISHIBASHI; Hiroyuki KOBAYASHI; Hiroyuki TSUJINO; Hitoshi NAGANO; Ichiro NAKAYAMA; Ikuji USAMI; Ippei FUJIMORI; Izumi HAYASHI; Joichi KATO; Jun GOTO; Junzaburo KABE; Kaneo SUZUKI; Kaoru OKADA; Kaoru OYAMA; Katsuhito ITO; Kazufuto FUKAYA; Kazukiyo OIDA; Kazunori KOZUMI; Kazuo SAKAMOTO; Kazuyoshi WATANABE; Keigo MAEHARA; Keimei MASHIMO; Keinosuke NOSE; Keizo MATSUMOTO; Keizo YAMAGUCHI; Kenichi OKAYAMA; Kenji TAKAMATSU; Kenji TAKAMURA; Kentaro WATANABE; Kinichi IZUMIKAWA; Kiyoshi KONNO; Kohei AOKI; Kohei HARA; Kohki KIKUCHI; Kohya SHIBA; Koichi WADA; Koichiro NAKATA; Kojiro YASUNAGA; Kosaku NAGAI; Kota KONO; Kotaro OIZUMI; Kou MUROHASHI; Kunihiko YOSHIMURA; Masaaki ARAKAWA; Masahide TAKII; Masahiko SEKI; Masahiro TAKAMOTO; Masahito KATO; Masakazu TAMURA; Masanori MATSUMURA; Masao TAMURA; Masaru KOYAMA; Masaru NASU; Masataka KATSU; Masatoshi WATANABE; Masayoshi SAWAKI; Masumi TOMIZAWA; Michisuke OHTA; Michiyasu NAKANISHI; Mikihiko TANGO; Mikio TAGUCHI; Minoru YOSHIDA; Minoru YOSHIYAMA; Mitsuru HAYASE; Naohiko CHONABAYASHI; Nobuki AOKI; Nobuo INABA; Nobuo OHYA; Osamu KURIMURA; Osamu SEKINE; Osamu YAJIMA; Riichiro MIKAMI; Rinzo SOEJIMA; Ryozo YONEDA; Ryuji HIROSE; Seibun YONEZU; Seiichi AONUMA; Shigeki ODAGIRI; Shinichi TANIZAWA; Shinichiro WATANABE; Shinya MIYAMOTO; Susumu HIRAGA; Tadashi MIYAHARA; Tadashi TAKIGAMI; Takashi ITO; Takashi ITOGA; Takayoshi TASHIRO; Takekuni IWATA; Tatsuo NAKATANI; Tetsuro UKAI; Tetsuto MURATA; Tomoko NIHEI; Toshihiko TAKEUCHI; Toshiro ODA; Toshiyuki YAMAMOTO; Toyoko OGURI; Tsugushi ITO; Tsuneo ISHIBASHI; Tsuneo MATSUBARA; Tsuyoshi NAGATAKE; Yasushi NAKAMURA; Yasutoshi SUZUKI; Yasuyuki HAYASHI; Yasuyuki SANO; Yoichiro GOTO; Yoji SUZUYAMA; Yomei HIRAGA; Yoshihiro UEDA; Yoshihito NIKI; Yoshimaru USUDA; Yoshio KOBAYASHI; Yoshio KURIHARA; Yoshiro SAWAE; Yoshitaka NAKAMORI; Yoshiteru SHIGENO; Yoshiyasu IKUNO; Yube IIDA; Yuruko OKAMOTO; Yutaka KANAZAWA; 三上 理一郎; 三木 文雄; 上田 良弘; 中山 一朗; 中村 靖; 中森 祥隆; 中田 紘一郎; 中西 通泰; 中谷 龍王; 丹呉 幹彦; 久世 文幸; 二木 芳人; 二瓶 倫子; 井上 英二; 今野 淳; 伊藤 亜司; 伊藤 勝仁; 伊藤 隆司; 佐々木 英夫; 佐野 靖之; 倉島 篤行; 前原 敬悟; 副島 林造; 加藤 政仁; 加藤 錠一; 勝 正孝; 原 耕平; 可部 順三郎; 吉村 邦彦; 吉田 稔; 和田 光一; 坂元 一夫; 大久保 滉; 大山 馨; 大泉 耕太郎; 大田 迪祐; 大谷 信夫; 宇佐美 郁治; 安永 幸二郎; 室橋 光宇; 宮原 正; 宮本 伸也; 富沢 磨須美; 小山 優; 小林 宏行; 小林 芳夫; 小栗 豊子; 小田 俊郎; 小田切 繁樹; 山作 房之輔; 山口 恵三; 山本 俊幸; 山本 朝子; 岡山 謙一; 岡本 緩子; 岡田 薫; 岩田 猛邦; 平賀 洋明; 平賀 進; 廣瀬 隆士; 後藤 純; 後藤 陽一郎; 斎藤 厚; 斎藤 玲; 斎藤 篤; 早瀬 満; 木積 一憲; 村田 哲人; 松原 恒雄; 松本 慶蔵; 松村 正典; 林 康之; 林 泉; 柴 孝也; 栗原 義夫; 栗村 統; 武内 俊彦; 武田 元; 氏家 昭; 永武 毅; 池本 秀雄; 池辺 璋; 河野 浩太; 泉川 欣一; 深谷 一太; 渡辺 一功; 渡辺 健太郎; 渡辺 正俊; 渡部 紳一郎; 滝上 正; 澤木 政好; 澤江 義郎; 瀧井 昌英; 生野 善康; 田代 隆良; 田口 幹雄; 田村 昌士; 田村 正和; 真下 啓明; 矢嶋 敢; 石橋 凡雄; 石橋 弘義; 福原 弘文; 種田 和清; 稲葉 宣雄; 篠田 厚; 米津 精文; 米田 良蔵; 糸賀 敬; 能勢 圭之助; 花木 英和; 荒川 正昭; 菊地 弘毅; 葭山 稔; 薄田 芳丸; 藤森 一平; 蝶名林 直彦; 西山 秀樹; 谷本 普一; 谷澤 伸一; 辻野 博之; 那須 勝; 重野 芳輝; 金沢 裕; 鈴山 洋司; 鈴木 周雄; 鈴木 康稔; 鍵岡 朗; 長井 弘策; 長野 準; 関 雅彦; 関根 理; 青木 信樹; 青木 幸平; 青沼 清一; 飯島 福生; 飯田 夕; 高本 正祇; 高村 研二; 高松 健次; 鵜飼 徹朗
Source
感染症学雑誌 / Kansenshogaku Zasshi. 1985, 59(7):708
Subject
Language
Japanese
ISSN
0387-5911
1884-569X
1884-569X
Abstract
The clinical effectiveness, safety and usefulness of sultamicillin tosilate (SBTPC) were compared with those of bacampicillin hydrochloride (BAPC) in patients with respiratory tract infections (RTI) by a double-blind study. RTI included in protocol were pneumonia, lung abscess and chronic RTI (chronic bronchitis, diffuse panbronchiolitis and other chronic RTI).SBTPC tablet (375 mg) or BAPC tablet (250 mg) was administered orally for 14 days at daily dose of 3 tablets, one tablet at a time, to assess clinical effectiveness, bacteriological response, side effects, laboratory findings and clinical usefulness.The following results were obtained:1) Number of patients: SBTPC and BAPC were administered to a total of 265 patients (134 on SBTPC and 131 on BAPC). Out of this, 33 patients were excluded or dropped out; clinical effectiveness was analyzed statistically in 232 patients (116 on SBTPC and 116 on BAPC). Side effects were evaluated in 256 patients (129 on SBTPC and 127 on BAPC).2) Clinical effectiveness: Clinical effectiveness rates by the committee judgement was 82.8%(96/116) for SBTPC and 69.8%(81/116) for BAPC, respectively; the statistical analysis revealed that SBTPC was significantly more effective than BAPC. Analysis based on the severity of infections showed that the clinical effectiveness of SBTPC (88.6%) in moderate infections was significantly superior to that of BAPC (65.5%). Furthermore analysis based on diseases showed that the clinical effectiveness of SBTPC (89.2%) in patients with chronic RTI was significantly superior to that of BAPC (63.2%).3) Bacteriological response: The bacteriological elimination rates of causative organisms was 75.4% for 70 strains treated with SBTPC and 65.2% for 72 strainstreated with BAPC, and the difference was not statistically significant.4) Time-course improvement of signs and symptoms and laboratory findings: On the 14th day or the final day of treatment, white blood cells count improved significantly more in the SBTPC group than in the BAPC group.Improvements of white blood cells count on the final day in the pneumonia group, of body temperature on the 14th day and on the final day, of sputum property in the 7th day and on the final day, and of white blood cells count on the final day of treatment in the chronic RTI group were superior in the SBTPC to the BAPC group.5) Side effect: Side effects were observed in 16.3% of 129 patients in the SBTPC group and in 6.3% of 127 patients in the BAPC group. SBTPC produced significantly more side effects than BAPC, but in most cases these side effects were mild and the severity of side effect was not significantly different between the both groups. Incidence of diarrhea observed in the SBTPC group was significantly more than that in the BAPC group, but no severe side effects affecting the prognosis were observed in the both groups. Abnormal laboratory findings, mainly transaminase elevations and eosinophil increase, were not significantly different between the two groups. The severity was mild in all cases except one in the BAPC group who showed a moderate degree of abnormal findings (elevations of GOT, GPT and Al-P).6) Usefulness: Usefulness rates judged by committee members for the SBTPC group and BAPC group were 77.1% and 66.9%, respectively, and these were not significantly different statistically.But rates of usefulness in the chronic RTI group was 83.6% for the SBTPC group and 61.0% for the BAPC group and the difference was significant. Also in the chronic RTI, usefulness rates judged by doctors in charge were 80.6% for the SBTPC group and 62.3% for the BAPC group, and this difference was statistically significant.From the above results it was concluded that usefulness of SBTPC was significantly superior to that of BAPC, being highly useful agent for the treatment of RTI, especially for chronic RTI.