부산대학교 도서관

An 83-year-old Japanese female, who was taking amlodipine besilate, presented to our department with asymptomatic eruptions, which had been present for several years. The eruptions had first developed on her distal lower legs and spread progressively upwards. A physical examination revealed 2-3-mm-sized patches of confluent telangiectasia on her lower extremities. Dermoscopy revealed fine arborizing vascular dilations. A histological examination demonstrated dilated blood vessels, which exhibited mural thickening and contained periodic acid-Schiff-positive eosinophilic material. An antibody to type IV collagen stained the basal walls of the dilated blood vessels. Based on these findings, we made a diagnosis of cutaneous collagenous vasculopathy (CCV). CCV is a rare microangiopathy of the dermal blood vessels of unknown cause. Approximately 60 cases of CCV have been reported in the English literature, and our case is the second case involving a Japanese patient. There are usually no symptoms other than telangiectasia. There is no effective treatment for CCV, but pulsed dye laser therapy has been suggested and was successful in some patients.