부산대학교 도서관

Extensive efforts to repair the extended criteria donor (ECD) grafts by machine perfusion has been reported. Although the optimal conditions, such as the perfusate, temperature, time, and the device, has not yet been established, organ perfusion is generally accepted as a promising concept. Here, we review current progress of antioxidant and anti-inflammatory treatment by induction of protective transcription factors (TFs), Nrf2 in relation to the other TFs (AP-1 and NF-kB). These TFs are mainly regulated by the redox status of intracellular thiols. Possible interactions of the TFs and the methods to regulate their activity have been described.