부산대학교 도서관

Esophagogastroduodenoscopy on a 44-year-old man revealed numerous white flattened polypoid lesions in the esophagus. Those elevations stained by lugol was classified as glycogenic acanthosis based from histopathological findings. Cowden’s disease was strongly suspected from the typical endoscopic findings. Since Cowden’s disease is one of multiple hamartoma syndrome, which manifest high incidence of benign/malignant tumors in skin mucosal abnormalities, breast, thyroid, endometrium, in addition to tumors in the gastrointestinal tract, thus other signs of tumor for other body parts of the patient was investigated. As a result, goiter, skin lesion, macrocephaly, mental development retardation and family history were confirmed from the investigation. Thus confirming the diagnostic criteria of a Cowden’s disease, and it is currently undergoing a follow-up observation. Since an example of Cowden’s disease, which is a relatively rare disease was experienced, thus a report including some literature considerations will be presented in this paper.