학술논문
Bronchopulmonary Lesions in Cases of Chronic Graft-versus-host Disease (cGVHD) / 慢性GVHDによる気管支肺病変
Document Type
Journal Article
Author
Arinobu TOJO; Eiichi SHINDO; Juzaburo MIYAKOSHI; Kaichi NISHIWAKI; Keisuke TOYAMA; Keiya OZAWA; Kenji TAJIKA; Kenzaburo TANI; Koji YANAGISAWA; Naoki UEMURA; Risa SHIRATO; Satoshi TAKAHASHI; Seiji IRIE; Shigetaka ASANO; Shinichiro OKAMOTO; Tokiko INOUE; Toru SHIMIZU; Toshiaki YUJIRI; Yasuo OSHIMA; Yoshifumi SHIMIZU; Yoshiyasu AOKI; Yuichi ICHINOSE; Yukio KOBAYASHI; 井上 登紀子; 入江 誠治; 外山 圭助; 大島 康雄; 宮腰 重三郎; 小林 幸夫; 小澤 敬也; 岡本 真一郎; 市瀬 裕一; 新道 英一; 東條 有伸; 柳沢 孝次; 植村 直樹; 浅野 茂隆; 清水 義文; 清水 透; 湯尻 俊昭; 田近 賢二; 白戸 りさ; 西脇 嘉一; 谷 憲三朗; 青木 克益; 高橋 聡
Source
臨床血液 / Rinsho Ketsueki. 1994, 35(1):23
Subject
Language
Japanese
ISSN
0485-1439
1882-0824
1882-0824
Abstract
We have studied bronchopulmonary lesions that developed in 3 allogeneic bone marrow recipients between days 120 and 250 post-transplant. Two cases had extensive chronic GVHD at the time of onset. All patients complained of low-grade fever, dry cough, and shortness of breath. The bronchopulmonary lesions were characterized by hypoxemia with increased AaDO2 and bilateral multiple non-circumscribed interstitial shadows on chest CT scan. Broncho-alveolar lavage (BAL) showed elevated numbers of lymphocytes in BAL fluid in all cases. BAL fluid was negative for CMV, pneumocystis carinii cysts, bacteriae and fungi in all cases. The results of transbronchial lung biopsy (TBLB) showed interstitial infiltration of lymphocytes in all 3 cases. The bronchopulmonary lesions were improved by either starting or increasing the dose of immunosuppressants. These findings and clinical courses suggest that the bronchopulmonary lesions in these patients were related to chronic GVHD.