학술논문
False-positive Elevation of Beta-D-glucan and Aspergillus Galactomannan Levels Due to Mendelson's Syndrome after Rice Aspiration
Document Type
Journal Article
Author
Ayumi Chikumoto; Junki Suizu; Kazuki Hamada; Kazuto Matsunaga; Keiji Oishi; Keita Murakawa; Kenji Sakamoto; Maki Asami-Noyama; Misa Harada; Nobutaka Edakuni; Sho Uehara; Syuichiro Ohata; Tasuku Yamamoto; Tetsuya Fujii; Tomoyuki Kakugawa; Tsunahiko Hirano; Yoriyuki Murata; Yoshikazu Yamaji; Yujiro Kikuchi; Yukari Hisamoto
Source
Internal Medicine. 2022, 61(19):2935
Subject
Language
English
ISSN
0918-2918
1349-7235
1349-7235
Abstract
Both 1,3-beta-D-glucan (BDG) and galactomannan (GM) are polysaccharide components of the fungal cell wall. Although elevated levels of serum BDG and Aspergillus GM suggest invasive fungal infection or Pneumocystis pneumonia and aspergillosis, respectively, it is also necessary to consider the possibility of false-positives. We herein report a 68-year-old man with marked elevation in serum BDG and GM levels accompanied by Mendelson's syndrome after rice aspiration. With the improvement of Mendelson's syndrome, his serum BDG and GM levels decreased. The false-positive serum BDG and GM findings may have been due to his aspiration of food containing them. It is important to take a detailed history of aspiration in addition to making a conventional differential diagnosis in patients with pneumonia with elevated serum BDG and GM levels.