학술논문
Estimation of Controlled Drug-release Behavior of Nano-porous Silica Micro Particles and Their Biocompatibility
Document Type
Journal Article
Author
Source
Nano Biomedicine. 2017, 9(2):112
Subject
Language
English
ISSN
1883-5198
2185-4734
2185-4734
Abstract
In this study, we investigated the controlled release behavior of a model drug from nanoporous silica microparticles (NPSM) contained in dental glass ionomer cement (GIC). NPSM released model drug molecules gradually in water for 2 weeks when they were contained in GIC. In contrast, GIC-only specimens released the molecule rapidly. To estimate the cytocompatibility of NPSM, osteoblastic cells were exposed to particles with various concentrations. At a concentration of 30 ppm, cell viability remained identical to that without exposure. In addition, mixing the particles did not affect their mechanical properties. These results suggest that NPSM can be used as a sustainable drug-release dental material.