부산대학교 도서관

Osteoarthritis （OA） is the most common joint disease associated with articular cartilage destruction. Matrix metalloproteinase-13 （MMP-13） and a disintegrin and thrombospondin motif-5 （ADAMTS-5）, which are enzymes that degrade the extracellular matrix, promote OA pathogenesis. We have recently shown that hydrogen peroxide-inducible clone-5 （Hic-5）, a mechanical stress-responsive adaptor molecule, promotes OA by inducing the expression of MMP-13 and ADAMTS-5 in chondrocytes in response to proinflammatory cytokines and mechanical stress. In this review, we discuss the potential of Hic-5 to be a therapeutic target for OA and the relevance of the focal adhesion molecules vinculin and talin to OA using single-cell data.