학술논문

The Novel Biomarkers-Based HALP (Hemoglobin, Albumin, Lymphocyte and Platelet)-Prognostic Model for Acute and Subacute Patients with Cerebral Venous Sinus Thrombosis: A Retrospective Cohort Study
Document Type
Journal Article
Source
Journal of Atherosclerosis and Thrombosis. 2023, 30(11):1742
Subject
Acute and subacute cerebral venous sinus thrombosis
Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP)
Prognostic model
Protective marker
Stroke
Language
English
ISSN
1340-3478
1880-3873
Abstract
Results: A total of 270 patients were included of which 31 had poor outcome. Multivariable logistic regression analysis demonstrated HALP (OR=0.978, 95%CI: 0.958-0.999, P=0.039) was a protective predictor of outcome. The AUC of HALP was 0.749 (95% CI: 0.633-0.865, P=0.044). DCA demonstrated that this model significantly improved risk prediction at threshold probabilities of CVST at 0 to 85% compared to ISCVT-RS scores. Patients with higher HALP (P=0.006) presented higher overall survival rates.