부산대학교 도서관

Genotoxicity of a widely used agricultural fungicide, Agrizim (carbendazim 50% w.p.), was assessed through chromosomal aberration and sister chromatid exchange (SCE) assays using in vitro human chromosomes in the presence and absence of exogenous metabolic activation. It induced, both with and without S9 fraction, dose and duration related statistically significant increase in the frequency of chromosomal aberrations but only its highest concentration increased the frequency of SCEs. The higher concentrations of Agrizim also caused other cytotoxic effects.