부산대학교 도서관

The centromere separation patterns in the bone marrow cells of Rattus norvegicus and Cavia porcellus were investigated. In both the species the separation was found to be nonrandom. In R. norvegicus the sequence of centromere separation was: chromosome 1 followed by chromosome numbers 15-21, 2, 3, 5-14 and 4 respectively.In C. porcellus chromosome X was the first one to show centromere separation and it was sequentially followed by chromosome numbers 17-31, 2-16 and 1.The administration of two Herbal Ayurvedic Drugs, Kynotomine and Tefroli, to R. norvegicus did not disrupt the sequential separation but caused significant delayment in the centromere separation.