학술논문
A Case Report of Lower Rectal Adenocarcinoma Treated by Transanal Endoscopic Microsurgery (TEM) in Combination with Preoperative Chemoradiation Therapy / 重篤な肺疾患のため化学放射線療法を施行後にTEMにより局所切除を行った下部直腸癌の1例
Document Type
Journal Article
Author
A. Matsuda; H. Kan; H. Suzuki; H. Tsuruta; J. Sasaki; K. Furukawa; N. Teranishi; S. Matsumoto; S. Shinji; T. Tajiri; Y. Akiya; 佐々木 順平; 古川 清憲; 寺西 宣央; 松本 智司; 松田 明久; 田尻 孝; 秋谷 行宏; 菅 隼人; 進士 誠一; 鈴木 英之; 鶴田 宏之
Source
日本大腸肛門病学会雑誌 / Nippon Daicho Komonbyo Gakkai Zasshi. 2007, 60(5):276
Subject
Language
Japanese
ISSN
0047-1801
1882-9619
1882-9619
Abstract
We herein report a case of lower rectal cancer complicated with idiopathic interstitial pneumonia which had a poor prognosis (3-year survival rate : 50%). We chose preoperative chemoradiation therapy : 5FU 600mg/body×5 days (d1-5, intravenous), CDDP 10mg/body×5 days (d1-5, intravenous), pelvic irradiation 40Gy in 20 fractions over 4 weeks. The tumor was resected by transanal endoscopic microsurgery (TEM) 5 weeks after the completion of the chemoradiation therapy. A histopathological study of the resected specimen showed well differentiated adenocarcinoma with submucosal invasion and the surgical margin was free of cancer. A year after the operation, computed tomography study showed no recurrences or metastasis. We concluded that preoperative chemoradiation therapy with a local resection of the tumor, such as TEM, may thus be an effective therapeutic alternative in some T1 and T2 cases of rectal cancer.