부산대학교 도서관

Pertussis is a severe infection that usually occurs in infancy. Patients who require extracorporeal membrane oxygenation (ECMO) support are at a high risk of death, and those that develop a thrombotic state during ECMO support need urgent attention and management. We report the case of a 46-day-old infant with severe Bordetella pertussis infection who required ECMO support and was suspected of having developed secondary thrombotic microangiopathy (TMA). He was transferred to our PICU due to apnea, respiratory failure, and hypoxemia caused by pertussis infection. He required ECMO support. Since early hospitalization, laboratory tests showed elevated LDH and free hemoglobin, along with the appearance of fragmented red blood cells; these findings were suggestive of thrombosis and hemolysis. Despite multiple interventions, the thrombosis and hemolysis did not improve. We diagnosed secondary thrombotic microangiopathy. Despite intensive care, the infant died. Pertussis infection can lead to secondary TMA, and urgent intervention is necessary; however, the pathophysiological pathways and optimal treatment for this condition are unclear.