학술논문

Allergen Stability and Immunological Reactivity during Co-dissolution and Incubation of House Dust Mite and Japanese Cedar Pollen SLIT-Tablets
Document Type
Journal Article
Source
Biological and Pharmaceutical Bulletin. :b20-00330
Subject
Allergen stability
Dual administration
House dust mite
Japanese cedar
Sublingual immunotherapy-tablet
Language
English
ISSN
0918-6158
1347-5215
Abstract
These results demonstrate that HDM or JCP major allergens and the total allergenic reactivity of both SLIT-tablets measured here remain intact after dissolution and co-incubation in human saliva, supporting the possibility of a dual HDM and JCP SLIT-tablet administration regimen if clinically indicated. The complete loss of allergenic reactivity after incubation in artificial gastric juice can furthermore be taken to indicate that the immunological activity of the allergen extracts contained in the two SLIT-tablets is likely to be lost or severely compromised upon swallowing.