학술논문
PHARMACOKINETIC AND CLINICAL STUDIES OF FLOMOXEF IN THE PERINATAL PERIOD / 産婦人科周産期領域におけるFlomoxefの基礎的・臨床的検討
Document Type
Journal Article
Author
HIROAKI HIRAYAMA; HIROAKI NEGISHI; HIROJI OKADA; HIROMITSU HAGA; HIROSHIGE MIKAMO; HIROYUKI TSURUTA; HISASHI TAKADA; HISATOMI MIZOGUCHI; JINSUKE YASUDA; KANGO FUKUNAGA; KAORU HANATANI; KATSUAKI KUNII; KAZUHIDE MURE; KAZUHIRO IWASAKU; KAZUO SENGOKU; KENICHI TAMATE; KINKI OH; KUNIHIKO ITOH; MASANORI IWAKI; MITSUHIRO KAWAMURA; MOTOKI HAYASAKI; MUTSUO ISHIKAWA; NANKUN CHO; NOBUYUKI MORISAKI; RYOICHI INOUE; SATORU MAKINODA; SEIICHIRO FUJIMOTO; SEIJI MATSUDA; SHIGEO SHIBATA; TAKAO YAMAMOTO; TENSYU HASEGAWA; TERUHIKO TAMAYA; TETSURO CHIMURA; TETSUYA SHIMIZU; TOHRU FUNAYAMA; TOSHINOBU TANAKA; TOYOICHI SAITOH; YOSHITAKA YAMADA; YUTAKA TORII; 三鴨 廣繁; 井上 亮一; 伊藤 邦彦; 千村 哲朗; 千石 一雄; 國井 勝昭; 安田 仁介; 山元 貴雄; 山田 新尚; 岡田 弘二; 岩城 雅範; 岩破 一博; 川村 光弘; 平山 博章; 斉藤 豊一; 早崎 源基; 松田 静治; 柴田 繁男; 根岸 宏明; 森崎 伸之; 清水 哲也; 溝口 久富; 牟禮 一秀; 牧野田 知; 玉手 健一; 玉舍 輝彦; 王 欣輝; 田中 俊誠; 石川 睦男; 福永 完吾; 船山 達; 花谷 馨; 芳賀 宏光; 藤本 征一郎; 長 南薫; 長谷川 天洙; 高田 久士; 鳥居 豊; 鶴田 浩之
Source
The Japanese Journal of Antibiotics. 1993, 46(7):568
Subject
Language
Japanese
ISSN
0368-2781
2186-5477
2186-5477
Abstract
Pharmacokinetic and clinical studies on flomoxef (FMOX) in the perinatal period were carried out and following results were obtained1. The pharmacokinetic parameter T 1/2's of FMOX in maternal serum, umbilical cord serum and amniotic fluid in mothers after single intravenous injection of 1g (n=46) and 2g(n=34) were 1.11, 9.24, 9.24 hours and 2.54, 12.49, 12.49 hours, respectively. Cmax's and Tmax's ofumbilical cord serum and amniotic fluid were 12.71, 11.77 μg/ml and 0.57, 3.35 hours upon single dose of 1 g i. v., and 35.17, 12.37 μg/ml and 0.32, 3.42 hours upon single dose of 2g i. v., respectively.2. Clinical usefulness were evaluated in 93 cases including were various infections in pregnancy and puerperal period. In pregnancy cases, clinical efficacy rate was 95.5% (21/22), and 100% in puerperal period.Bacteriological response rate was 84.6% (eradicated: 29, decreased: 4, unchanged: 2, replaced: 4 and unknown: 8 cases).No severe side effects nor clinical laboratory test results were observed in any cases.From above basic and clinical results, we conclude that FMOX is a useful and safe agent for various infections in pregnancy and puerperal period.