부산대학교 도서관

Serum thyroid hormone and TSH concentrations were measured before and after the administration of TRH (10μg/kg body weight) and bovine TSH (10 IU) in 14 children with chronic lymphocytic thyroiditis.The TRH test showed that the responsiveness of TSH was positively correlated with the basal TSH (P<0.001) and inversely with the increase in serum thyroid hormones, for ΔT3 (P<0.05) and for ΔT4 (P<0.001). Overall, the patients had significantly lower mean values for basal T4, but not for T3.The TSH test revealed that the ΔT3 was positively correlated with ΔT4 (P<0.05).ΔT3 after TSH administration was positively correlated with it after TRH (P<0.05).The patients were divided into three groups on the basis of their peak TSH values after TRH administration. In Group 1 (peak value below 40 μU/ml; N=5); T3 increased significantly after TRH and TSH administrations (P<0.05 and P<0.025, respectively). In addition, ΔT4 was significant after TSH administration. In Group 2 (peak TSH above 40 and less than 100 μU/ml; N=6); only ΔT3 after TRH was significant (P<0.05). In Group 3 (peak TSH above 100 μU/ml; N=3); the response of thyroid hormones was blunted. Thus, the thyroid hormone responses to endogenous TSH coincided with that to exogenous TSH, and the exaggerated TSH response to TRH indicates decreased thyroid reserve.