부산대학교 도서관

We report a case of multiple metastases of ampullary carcinoma, which completely responded to intrahepatic infusion of continuous 5-FU and low dose CDDP for about 4 months. A 61-year-old woman underwent a pylorus-preserving pancreatoduodenectomy for an ampullary carcinoma. One year after the operation, a single hepatic metastasis was found and enucleated. Thereafter a subcutaneous reserver for hepatic arterial infusion was placed and 2mg of MMC had injected three times. Eight months after the second operation, multiple liver metastases and swelling of lymph nodes were pointed out, with an increase in CEA and CA 19-9. Hepatic arterial infusion with 5-FU and CDDP at doses of 250mg/5h and 5mg/bolus respectively was per-formed 18 times every 3 days. Two months later, the multiple liver metastases completely disappeared with great decreases in tumor markers. Since the lymph nodes had increased in size, systemic chemotherapy was added. CR for liver metastases was obtained by this regimen and lasted for about 4 months, but recurrence of multiple hepatic metastases and poor patient's condition obliged us to finish the chemotherapy. The patient died 25 months after the initial operation.