부산대학교 도서관

The patient was a 67-year-old man. He had erythema associated with itching over his entire body for about four months, and developed hoarseness one month prior to visiting a clinic. A chest X-ray revealed a nodule in the left upper lobe of the lung, and he was referred to our hospital. At the rst examination of the skin, we observed facial erythema, polymorphic skin atrophy, and Gottron’ssign. He did not have myopathy or an increase in creatine kinase (CK) or aldolase. However, he was positive for anti-TIF1-antibody and was diagnosed with amyopathic dermatomyositis (ADM). By bronchoscopy, the nodule found in the left upper lobe of the lung was determined to be squamous cell carcinoma. We describe this case as anti-TIF1 antibody-positive amyopathic dermatomyositis with squamous cell carcinoma of the lung. The diagnostic criteria for polymyositis and dermatomyositis in Japan were revised in 20151). This has made it possible to diagnose ADM according to skin symptoms based on the same pathological ndings as those of dermatomyositis. However,dermatomyositis shows only slight pathological changes, precluding the denite diagnosis of ADM and possibly delaying treatment. Recently, novel myositis-specic autoantibodies highly specicto polymyositis and dermatomyositis have been identied. They are closely associated with the disease type, pathology, clinical course, and therapeutic response of myositis ; therefore, they should be useful for deciding the treatment policy and predicting disease activity for ADM. Skin Research, 17 :239-244, 2018