학술논문

The effect of changes in dosimetry on cancer mortality risk estimates in atomic bomb survivors
Document Type
Journal Article
Source
The Japan Radiation Research Society Annual Meeting Abstracts. 2004, :49
Subject
Language
English
Abstract
The Radiation Effects Research Foundation (RERF) has implemented a new dosimetry system DS02 to replace the DS86. The primary change is an increase of about 10 % in gamma dose estimates for both cities. An anticipated increase of the neutron component in Hiroshima, for low-dose survivors, did not materialize. Risk estimates based on DS02 and DS86 doses were compared for solid cancer and leukemia mortality in the RERF Life Span Study (LSS) cohort for the period 1950 through 2000. Among about 86,000 survivors there were about 10,000 solid cancer and about 300 leukemia deaths. The estimates of solid cancer risk/Sv and the nonlinear dose response for leukemia are both decreased by about 10 % by the dosimetry revision. Estimated age-time patterns and sex difference are virtually unchanged by the dosimetry revision. The apparent shape of the dose response is virtually unchanged by the dosimetry revision, but for solid cancers the additional 3 years of follow-up from the LSS Report 13 has some effect. There is for the first time statistically significant upward curvature on the dose range 0-2 Sv. However, the low-dose slope of a linear-quadratic fit to that dose range should probably not be relied on for risk estimation, since that is substantially smaller than the linear slopes on ranges 0-1 Sv, 0-0.5 Sv, and 0-0.25 Sv.

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