학술논문
Efficacy and Safety of Cryoballoon Ablation in Patients With Heart Failure and Reduced Left Ventricular Ejection Fraction ― A Multicenter Study ―
Document Type
Journal Article
Author
Amr Abdin; Andreas Metzner; Andreas Rillig; Britta Goldmann; Bruno Reissmann; Charlotte Eitel; Christian-Hendrik Heeger; Christine Lemeš; Feifan Ouyang; Julia Vogler; Karl-Heinz Kuck; Kivanc Yalin; Peter Wohlmuth; Riccardo Proietti; Roland Richard Tilz; Roza Meyer-Saraei; Shibu Mathew; Spyridon Liosis; Thomas Fink; Tilman Maurer; Tobias Graf
Source
Circulation Journal. 2019, 83(8):1653
Subject
Language
English
ISSN
1346-9843
1347-4820
1347-4820
Abstract
Methods and Results:CB2-based PVI was performed in 551 consecutive patients in 3 highly experienced EP centers. Patients with HF and LVEF ≤40% were included (HFrEF group, n=50/551, 9.1%). Data were compared with propensity score-matched patients without HF and preserved left ventricular EF (LVEF) (n=50, control group). The median LVEF was HFrEF: 37% (35, 40) and control: 55% (55, 55), P<0.0001. Major periprocedural complications were registered in 4/50 (8%, HFrEF group) and 3/50 (6%, control group), P=0.695. The 12-month freedom from AF recurrence was 73.1% (95% confidence interval (CI): 61–88, HFrEF group) and 72.6% (95% CI: 61–87, control group), P=0.25. NYHA class decreased from 2.4±0.8 (baseline) to 1.7±0.8 at 12-month follow-up (P<0.0001). LVEF improved from a median of 37% (35, 40) prior to ablation to a median of 55% (40, 55), P<0.0001.