학술논문
Anticancer drug nilotinib-induced electrical, calcium, and mechanical alternans in human iPS cell-derived cardiomyocyte sheets / ヒトiPS細胞由来心筋細胞シートにおける抗がん薬ニロチニブ誘発性電気的・カルシウム・機械的オルタナンス
Document Type
Journal Article
Author
Source
Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2023, :3-1
Subject
Language
Japanese
ISSN
2435-4953
Abstract
Results: Nilotinib induced EADs in every excitation for the most part, but excitation without EAD showed up intermittently, and EADs were sometimes terminated by electrical pacing via the MEA system, which depended on the pacing cycle lengths. Alternate phenomena of FP duration (FPD) were observed with and without EAD, which also caused alternans in the conduction speed, contraction velocity and peak amplitude of Ca peak along with Ca transient duration. During electrical pacing, electrical excitations with EADs induced conduction delays upon the next one without EAD. Transient loss of EAD increased the conduction speed, contraction velocity and Ca peak amplitude of the cell sheets upon the next electrical excitation, indicating that the shorter FPD enhanced the recovery of Ca and Na channels from their inactivation state. Alternans was not observed when only action potentials without EAD or with EAD were sustained.