부산대학교 도서관

In a clinical investigation of early postoperative prognosis following hepatectomy for hepatocellular carcinoma with liver cirrhosis, human hepatocyte growth factor (hHGF) was measured during the past 21 months. The preoperative hHGF value was significantly correlated with the values of the conventional liver function test, and it was evaluated as an indicator of early postoperative prognosis after hepatectomy (p=0.0001). The postoperative pattern of the hHGF level was correlated with intraoperative stress degree (ISD) as evaluated by arterial ketone body ratio (AKBR) and postoperative clinical course. In an experimental study to examine the correlation between postoperative clinical course and the pattern of hHGF, hHGF was added to normal cultured hepatocytes or ones damaged by CCl4 or chemical hypoxia. It was found that the normal Ca2+ response induced by hHGF was suppressed depending on the dosis of CCll4 or duration of hypoxia. Moreover, elevations of GOT, GPT and LDH in the supernatant were more significant after the stimulation of hHGF. As a conclusion, it was recommended that measurement of hHGF might be effective as an indicator of the preoperative live function or the early postoperative prognosis after hepatectomy, and its postoperative pattern was evaluable as a parameter for liver dysfunction.