학술논문
Detection of brain function disruption caused by nicotinic acetylcholine receptor agonists using Ca2+ imaging with two-photon microscopy / 二光子顕微鏡を用いた、ニコチン性アセチルコリン受容体アゴニストによる脳機能障害の検出
Document Type
Journal Article
Author
Anri HIRAI; Collins NIMAKO; Hiroaki WAKE; Kazutoshi FUJIOKA; Keisuke KATO; Keisuke TAKAHASHI; Koji ARIZONO; Kumiko TAIRA; Mayumi ISHIZUKA; Nobuhiko HOSHI; Shouta M.M. NAKAYAMA; Shouta SUGIO; Tetsushi HIRANO; Yoshinori IKENAKA; 中山 翔太; 加藤 恵介; 和氣 弘明; 平 久美子; 平井 杏梨; 平野 哲史; 星 信彦; 有薗 幸司; 杉尾 翔太; 池中 良徳; 石塚 真由美; 藤岡 一俊; 高橋 圭介
Source
Annual Meeting of the Japanese Society of Toxicology. 2021, :P-37
Subject
Language
Japanese
Abstract
Neonicotionoid pesticides are insecticides which have been thought to be one of the causes of Colony Collapse Disorder. They were considered to be less toxic to mammals than insects, but some of the recent studies suggested their association with disruption of higher brain fuction in mammals. Nevertheless, it is still unclear how neonicotionoids affect on the central nervous system. Here, we propose the use of in vivo Ca2+ imaging with two-photon microscope to detect abnormal activity of neuronal circuits in brain with the application of neonicotionoids.