부산대학교 도서관

Tobramycin was investigated especially in the view of its therapeutic use for septicemia due to gram negative rods, and the following results were obtained.1. The antibacterial activity of tobramycin against P. aeruginosa was 2 to 4 times stronger than that of gentamicin.2. Tobramycin was almost same as gentamicin in activity against S. aureus, E. coli, Klebsiella and Enterobacter, but it was less than gentamicin against Serratia.3. Tobramycin showed a good sensitivity against Salmonella and Listeria monocytogenes, but resistant to Bacteroides fragilis.4. A good in vitro synergic action of both bacteristatic and bactericidal was observed in Klebsiella with combination of tobramycin and cephalothin, and it was observed at the concentration of more than 0.39 μg/ml or at least 0.2μg/ml of tobramycin.5. Tobramycin was given to 4 cases of septicemia due to gram negative rods, and effective response was observed in each one case with Klebsiella or P. aeruginosa. It was failure in one case with E. colt to which both tobramycin and gentamicin were resistant, and it was unevaluable in one case with P. aeruginosa.6. In 2 cases with P. aeruginosa, the causative organisms were isolated during the administration of gentamicin at 120 and 160 mg per day, although bath organisms were sensitive (MIC : 3.13 μg/ml) to the drug.