부산대학교 도서관

To investigate the efficacy of a bath additive containing a diamide derivative in patients with atopic dermatitis, two test materials were prepared for a clinical test. One was a bath additive containing the diamide derivative, eucalyptus extract, oat extract and oily moisturizing ingredients such as a synthetic pseudo-ceramide. The other was the same product depleted of the diamide derivative, which was used as a placebo. Both bath additives had the same color and fragrance when dissolved in bath water. Twenty-one patients with atopic dermatitis bathed with either the bath additive containing the diamide derivative (diamide-derivative group: 13 cases) or the placebo (placebo group: 8 cases). The clinical test was performed under double-blind conditions and the usage period was 3-6 weeks. In the clinical test, although a significant improvement in “skin dryness” and “desquamation” was recognized in both groups, “itching and scratch marks” and “skin conductance” were improved significantly only in the diamide-derivative group. In 14 patients (7 cases in each group) who used the bath additives at higher frequency (more than 4 times per week), the “itching score” during bathing was improved in the diamide-derivative group, but without significance (p=0.074), and was significantly improved after bathing (p<0.05). However, in the placebo group, the “itching score” was not improved either during or after bathing. With regard to the number of patients whose “itching score” after bathing was improved, the number of subjects in the diamide-derivative group was significantly greater than in the placebo group (p<0.05). Thus, the bath additive containing the diamide derivative may be useful for patients with atopic dermatitis as a skin care preparation.