부산대학교 도서관

The strain of FGS/Nga mouse was reported to develop proteinuria and progressive glomerulosclerosis. It was established from cross between CBA/Nga and RFM/Nga mice in the Laboratory of Animal Genetics, Faculty of Agriculture, Nagoya University. We studied clinical parameters and the renal pathology of the strain. Proteinuria began to appear at the age of 2 months and increased thereafter. No hematuria was observed throughout the experiment. The level of serum creatinine increased at 6 months of age and some mice showed oliguria after 10 months.By light microscopy, mild glomerular proliferation was observed within three months. Focal segmental glomerulosclerosis was observed 3 months after birth and the sclerotic changes increased by 6 months. The lesion progressed to the glomerular obsolescence in a year. Electron microscopic study revealed electron dense deposits (DD) in the mesangial area. The splitting of glomerular basement membrane was also observed. Studies using immunofluorescent microscopy revealed the deposition of IgG, IgA, IgM and C3 in the mesangial area. These data suggest that this strain of mouse provides us an useful tool (animal model) for studying mechanisms of human chronic glomerulopathy.