부산대학교 도서관

A 41-year-old man was admitted to our hospital because of anorexia, malaise and fever. Endoscopic examination performed at our hospital showed diffuse white villi in the duodenum. Based on histopathologic examination of biopsy specimens obtained from the same site, he was diagnosed with Whipple’s disease. Treatment with antibiotics was started. Endoscopic images and histopathological images were evaluated at approximately 2 months and 8 months after diagnosis, and showed improvements over time. In most recent reports of this disease in Japan, Whipple’s disease was diagnosed based on observation of white villi in the duodenum, which is considered to be a very useful finding for the diagnosis of this disease. It is difficult to diagnose Whipple’s disease from the patient’s symptoms alone. Our patient had no background that would cause immune deficiency. This case is considered to be a valuable case in which we could confirm changes in the endoscopic images and pathological findings of Whipple’s disease over time.