학술논문
Changes in expression of fibrosis-related factors in alveolar epithelial cells and macrophages by forced expression of p16 / p16の強制発現による肺胞上皮細胞およびマクロファージにおける線維化関連因子の発現の変化
Document Type
Journal Article
Author
Source
Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2021, :1-LB48
Subject
Language
Japanese
ISSN
2435-4953
Abstract
We reported that alveolar epithelial cells and macrophages undergo cellular senescence in the lungs of bleomycin-induced pulmonary fibrosis model mice. However, the effect of each cell senescence on fibrosis has not been clarified. In this study, we investigated changes in the expression of fibrosis-related factors using senescent cells in which p16, an important cellular senescence-inducing factor, was forcibly expressed using lentivirus vector.