부산대학교 도서관

The MIC of AM-715 was determined against 61 strains of clincially isolated S. typhi, and then compared with those of chloramphenicol, ampicillin, nalidixic acid, piromidic acid, pipemidic acid and miloxacin in inoculum size of 106 cells/ ml. The antimicrobial potency of AM-715 was much greater than those of other antibacterial agents tested.AM-715 was administered to 7 cases of typhoid fever, 4 cases of asymptomatic fecal excretor of S. typhi, one case of asymptomatic fecal excretor of S. paratyphi B with gall stones and 6 cases of salmonellosis other than typhoid fever.Daily dosis of AM-715 to the typhoid fever were 800 mg to 2 cases, 1, 200 mg to 2 cases and 1, 600 mg to remaining 3 cases respectively. The cases which were treated with the daily dosis of 1, 600 mg were completely cured after the 14 days medication. In the cases of the daily dosis of 800 mg, clinical effect was not observed. In the cases of the daily dosis of 1, 200 mg, clinical response was observed good in one case, and poor in another case.To the asymptomatic fecal excretor of S. typhi and S. paratyphi B, daily dosis of 1, 200 mg of AM-715 were administered for over two weeks. But the boy of 12 years old was medicated with the daily dosis of 800 mg of the drug. The eradication of the bacilli was succeeded in all cases.To the salmonellosis other than typhoid fever, AM-715 was administered with the daily dosis of 1, 200mg for a week. All cases were cured and the bacilli in their feces were disappeared.No adverse reaction was observed with the exception of a slight elevation of the serum bilirubin value in one case.