학술논문
Clinical Evaluation of Sulindac (CLINORIL ®) in the Treatment of Acute Upper Respiratory Tract Infection Double-Blind Comparison with Ibuprofen / 急性上気道炎に対するSulindac (CLINORIL ®) の薬効評価
Document Type
Journal Article
Author
Fumio YAMAZAKI; Fuyuhiko HIGASHI; Hiroshi NAKAGAWA; Hiroshi TAKEDA; Hisao OHSUGA; Ippei FUJIMORI; Kengo OHTSUBO; Kohji OGIHARA; Kohjiro SEKITA; Koji SEKI; Kuniyoshi IIZUKA; Masakatsu HAYAKAWA; Masanori ADACHI; Masataka KATSU; Michinori KOHNO; Nobuyuki GONDA; Sacchu SHIMADA; Satoshi SASAKI; Shinichi ENOMOTO; Shohkichi YAMAZAKI; Shuji ITOH; Tatsuo NOGUCHI; Tetsuo TAMAGAWA; Yasuo MATSUKI; Yoshihiko TAKEDA; 中川 浩; 伊藤 周治; 佐々木 智也; 勝 正孝; 大坪 謙吾; 大菅 久夫; 安達 正則; 山崎 富美夫; 山崎 昭吉; 島田 佐仲; 早川 正勝; 東 冬彦; 松木 康夫; 榎本 新市; 権田 信之; 武田 宏; 河野 通律; 玉川 鉄雄; 竹田 義彦; 荻原 宏治; 藤森 一平; 野口 龍雄; 関 浩二; 関田 恒二郎; 飯塚 邦芳
Source
感染症学雑誌 / Kansenshogaku Zasshi. 1983, 57(3):260
Subject
Language
Japanese
ISSN
0387-5911
1884-569X
1884-569X
Abstract
A multi-clinic double-blind study in comparison with ibuprofen was conducted to evaluate the effectiveness, safety and usefulness of sulindac, a new non-steroidal analgesic/anti-inflammatory agent, in acute upper respiratory tract infection. Patients were treated with sulindac 150mg twice a day or ibuprofen 300 mg three times a day for 4 days.The effectiveness and usefulness were statistically analyzed and compared in 141 sulindac-treated and 150 ibuprofen-treated patients; safety was similarly assessed in 144 and 152 patients, respectively.The sulindac group was superior to the ibuprofen group in improvement of headache, low back pain and tonsil redness on the 3rd day, and in low back pain on the 5th day.Not statistically significant difference was observed in the final global evaluations of the effectiveness, safety or usefulness. Therefore, sulindac is considered to be a highly useful drug equivalent or superior to ibuprofen in the treatment of acute respiratory tract infection.