학술논문
Fundamental and Clinical Studies on Intravenous Drip Infusion of HAPA-B / HAPA-B点滴静注の基礎的・臨床的検討
Document Type
Journal Article
Author
Akio AOYAGI; Akira FUJII; Akira SAITO; Atsushi KONDO; Atsushi SAITO; Etsuji TAKASAKI; Fumio MATSUMOTO; Fuyuhiko HIGASHI; Hajime YAMAGATA; Hideo OOSHIMA; Hiroichi KISHI; Hiromi KUMON; Hiroshi KAWANE; Hiroshi KIYOTA; Hiroshi OKUBO; Hiroshi OSHITANI; Hiroyuki KOBAYASHI; Hiroyuki OHMORI; Hisako SUZUKI; Ichiro NAKAYAMA; Ippei FUJIMORI; Isao MURAHASHI; Isao SAITO; Joichi KUMAZAWA; Joji ISHIGAMI; Kaneo SUZUKI; Kaoru OKADA; Kaoru OYAMA; Katsuichi NANBA; Katsumi ENDO; Katsuo TAKANASHI; Katsuyoshi KONDO; Katsuyuki MITOBE; Kazunori OISHI; Kazuo TAKEBE; Keiichi MIKASA; Keisuke TOYAMA; Keizo MATSUMOTO; Keizo SUZUKI; Keizo YAMAGUCHI; Kenichi SAITO; Kihachiro SHIMIZU; Kohei HARA; Kojiro YASUNAGA; Koou MUROHASHI; Masahiko YOSHIDA; Masahiro KIZAKI; Masanori MATSUMURA; Masaru SUMI; Masashi YONEDA; Masataka KATSU; Masayoshi SAWAKI; Michifumi ADACHI; Minoru SATOH; Mitsuo KITAHARA; Mitsuyo KIUCHI; Noriaki TANAKA; Riichiro MIKAMI; Rinzo SOEJIMA; Sadao KAMIDONO; Seibun YONEZU; Shigeki ODAGIRI; Shigeru KOHNO; Shinichi KAJI; Shinji OKUI; Shoichi ONODERA; Tadao NIIJIMA; Takakazu KIYA; Takashi INAMATSU; Takashi TOMINAGA; Takeshi ISHIZAKI; Tetsuro MATSUMOTO; Tetsuzo KANESHIGE; Toshiaki YOSHIDA; Toshimi TAKEUCHI; Toshio KISHIMOTO; Toyohei MACHIDA; Toyokazu TAMURA; Tsuneo NISHIURA; Tsutomu FUKUDA; Yasuharu NAKANO; Yasuhiro YOSHIIKE; Yasumasa DOHTSU; Yasunori ISHII; Yasuo IDO; Yasushi UEDA; Yoji SUZUYAMA; Yoshiaki KUMAMOTO; Yoshihiro UEDA; Yoshihito NIKI; Yoshio KOBAYASHI; Yoshiro SAWAE; Yoshiteru SHIGENO; Yoshito BAN; Yoshitsugu NASU; Yukinori TAKAHASHI; Yukio KUMAGAI; Yuruko OKAMOTO; Yuzo FUNATSU; 三上 理一郎; 三笠 桂一; 上田 泰; 上田 良弘; 中山 一朗; 中野 康治; 二木 芳人; 井戸 康夫; 佐藤 実; 公文 裕巳; 副島 林造; 加治 慎一; 勝 正孝; 北原 光夫; 原 耕平; 吉池 保博; 吉田 俊昭; 吉田 雅彦; 坂 義人; 外山 圭助; 大久保 滉; 大山 馨; 大島 秀夫; 大森 弘之; 大石 和徳; 奥井 津二; 守殿 貞夫; 安永 幸二郎; 安達 倫文; 室橋 光宇; 富永 登志; 小林 宏行; 小林 芳夫; 小田切 繁樹; 小野寺 昭一; 山口 恵三; 山縣 元; 岡本 緩子; 岡田 薫; 岸 洋一; 岸本 寿男; 川根 博司; 押谷 浩; 斉藤 功; 斉藤 賢一; 斎藤 厚; 斎藤 玲; 斎藤 篤; 新島 端夫; 木内 充世; 木崎 昌弘; 木谷 崇和; 村橋 勲; 東 冬彦; 松本 哲朗; 松本 慶蔵; 松本 文夫; 松村 正典; 武部 和夫; 水戸部 勝幸; 河野 茂; 清水 喜八郎; 清田 浩; 澤木 政好; 澤江 義郎; 熊本 悦明; 熊澤 浄一; 熊谷 幸雄; 田仲 紀明; 田村 豊一; 町田 豊平; 石井 泰憲; 石崎 驍; 石神 襄次; 福田 勉; 稲松 孝思; 竹内 敏視; 米津 精文; 米田 政志; 船津 雄三; 藤井 明; 藤森 一平; 西浦 常雄; 角 優; 近藤 捷嘉; 近藤 淳; 道津 安正; 遠藤 勝実; 那須 良次; 重野 芳輝; 金重 哲三; 鈴山 洋司; 鈴木 周男; 鈴木 尚子; 鈴木 恵三; 難波 克一; 青柳 昭雄; 高崎 悦司; 高梨 勝男; 高橋 幸則
Source
感染症学雑誌 / Kansenshogaku Zasshi. 1986, 60(11):1216
Subject
Language
Japanese
ISSN
0387-5911
1884-569X
1884-569X
Abstract
The clinical efficacy and safety of HAPA-B, a new aminoglycoside, was investigated fundamentally and clinically by intravenous drip infusion for internal (81 Cases) and urological (101 Cases) field infections. The following results were obtained.1. After 1 hour infusion of 200 mg of HAPA-B, the mean value of peak serum and plasma concentration was 14.13±4.44μg/ml at the termination of infusion. In patients with impaired renal function, the plasma concentration of HAPA-B tended to be maintained higher and urinary recovery rates after 12 hrs found decreased in parallel with the decreased value of creatinine clearance.2. Clinical efficacy of HAPA-B on internal field infections were 70.5%(43/61) for respiratory tract infections, 100%(6/6) for urinary tract infections and 100%(7/7) for other infections, respectively, with a total effectiveness rate of 75.7%. Its bacteriological efficacy was 62.5%.3. Clinical effectiveness rate of HAPA-B on urological field infections was 61.2%(60/98) by doctor's evaluation. According to the criteria of UTI committee, the effectiveness rate was 54.9%(50/91) and the bacteriological efficacy was 68.3%.4. Clinical symptoms seemed to be side effects were observed in three cases (1.6%) of 182 cases and abnormal laboratory findings were observed in nine cases. But all of them were transient without severe reactions observed.5. It was suggested from these investigations that intravenous drip infusion of HAPA-B was as effective and safe as intramuscular injection. Therefore, the intravenous drip infusion of HAPA-B will be useful for treatment of infections.