부산대학교 도서관

It has been reported that combined use of antibiotics and phenylbutazone (PB) in infectious diseases has “synergistic” effects similar to that of antibiotics and adrenocorticosteroid. Twenty four cases (5 typhoid fever, 3 pneumonia, 1 pyothorax, 10 exsudative pleuritis and 5 pulmonary tuberculosis) were treated by the author et al, PB being administered continuously for 7-14 days or more with a daily dosis from 200 to 600 mg.Antipyretic effect was noted in most of the cases within 1-2 days, associated with improvement of erythrocyte sedimentation rate, leucocytosis, CRP, A/G ratio and chest. x ray findings as well as subjective signs. However, these effects were delayed few days in some cases.The combined therapy with antibiotics and PB was effective in all 5 cases of typhoid fever, all 3 cases of pneumonia and 8 out of 10 cases of exsudative pleuritis. It failed to be effective in pyothorax and all five cases of pulmonary tuberculosis. Consequently, it was effective in 16 out of 24 cases (67%) and not effective in 8 cases (33%). On the other hand, decreased urine output, proteinuria, glycosuria, hematuria, skin rash and gastrointestinal disturbance were noted in almost half of the cases as side effects, which, however, were not serious enough to discontinue medication except in 3 cases.A single oral administration of 600 mg PB to normal adult demonstrated a decrease of 17-OHCS in blood in 6 hours, whereas simultaneously taken blood level of PB showed maximum concentration in 6-8 hours.Reviewing 24 cases, combined therapy was effective when administered in acute: phase, especially within 14 days. Long term therapy was ineffective in most of the cases, for effecacy of this therapy could be expected even in short term administration. Summing up the results, though the combined therapy with antibiotics and PB was inferior to that. of antibiotics and adrenocorticosteroid in its efficacy, it is of note for new therapeutic. approach to infectious diseases, since less side effects were noted in the former than is the latter.