부산대학교 도서관

Case 1: A 66-year-old man presented with 3 slow-growing nodules on the left forearm and left brachium that had developed approximately 6 months prior to his consulting our clinic. Histologic examination indicated that one of these nodules was a sebaceoma and the others were low-grade sebaceous carcinomas. His medical history included sebaceomas at the age of 51 and 53, respectively, a transitional cell carcinoma of the urinary tract at the age of 53, a keratoacanthoma on the hip at the age of 60 and a colon carcinoma at the age of 64. Family history indicated that the patient’s father and younger brother had gastric cancer, an older brother had pancreatic cancer and a niece had uterine cancer. Case 2: A 57-old man presented with a small nodule on his forehead that had been present for 2 years and had enlarged gradually and became erosive. The skin lesion was excised and histologically identified as a sebaceoma. This patient had urinary tract cancers at the ages of 48 and 56, respectively, colon and rectal cancer at the age of 48 and bladder cancer at the age of 57. His mother died of rectal carcinoma at the age of 56. Both case 1 and case 2 had sebaceous tumors, and, additionally, previously had internal malignancies as well as a family history of internal malignancies. Therefore, we diagnosed these two cases as Muir-Torre syndrome.