부산대학교 도서관

Cefepime (BMY-28142, CFPM), a new parenteral cephalosporin was evaluated for itsin vitroandin vivoantibacterial activity and compared it with ceftazidime (CAZ), cefuzonam (CZON), cefotaxime (CTX)and cefmenoxime (CMX). CFPM showed a wellbalanced, broad spectrum of activity against a number of clinical isolates. The activity of CFPM against Gram-positive bacteria was several times greater than that of CAZ, nearly comparable to CTX and CMX, and slightly weaker than CZON. Enterobacteriaceae, CFPM showed superior activity to the reference cephalosporins againstProvidencia stuartii, Providencia rettgeri, Morganella morganii, Citrobacter freundiiandEnterobacter cloacae. The activity of CFPM againstPseudomonas aeruginosawas comparable to that of CAZ. CFPM was more stable than CZON, CTX and CMX to various types of β-lactamases from Gram-negative bacteria. The bactericidal activity of CFPM was demonstrated by a time-kill curve withEscherichia coliandP. aeruginosa. CFPM resulted in a time-kill curve similar to that of CAZ. The highin vitroactivity of CFPM was reflected in itsin vivoefficacy against experimental infections in normal and immuno-suppressed mice. CFPM was the most effective among the cephalosporins tested against Gram-negative bacteria infections.