학술논문
Role of the microsomal prostaglandin E synthase-1 in imiquimod-induced psoriasis-like skin inflammation. / イミキモド誘発乾癬様皮膚炎における膜型プロスタグランジンE合成酵素-1の役割
Document Type
Journal Article
Author
Source
Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2022, :2-090
Subject
Language
Japanese
ISSN
2435-4953
Abstract
Results: The expression of mPGES-1 was highly induced on both mRNA and protein levels in the skin of WT mice after IMQ administration. Interestingly, the mPGES-1−/− mice exhibited more severe symptoms of psoriasis-like skin inflammation compared to those of WT mice during administration of IMQ. Histological analysis further showed significant increase of epidermal thickness in mPGES-1−/− mice. The skin expression of IL-17A, a prominent target for the treatment of psoriasis, was highly up-regulated in mPGES-1−/− mice in response to IMQ administration.