학술논문
Characteristics of cases of hepatitis E in 2019 in Gunma prefecture: a small epidemic caused by the same subgenotype 3a strain / 群馬県における2019年のE型肝炎症例の特徴：同一3a型株による小流行
Document Type
Journal Article
Author
Atsushi Naganuma; Daichi Takizawa; Daisuke Uehara; Hiroaki Nakajima; Hiroaki Okamoto; Hiroki Tojima; Hitoshi Takagi; Ken Sato; Masaharu Takahashi; Satoru Kakizaki; Satoshi Takakusagi; Shigeo Nagashima; Takashi Kosone; Takashi Ueno; Takayoshi Suga; Takeshi Hatanaka; Toshio Uraoka; Yuichi Yamazaki; Yuki Kanayama; 上野 敬史; 中島 弘明; 佐藤 賢; 小曽根 隆; 山崎 勇一; 岡本 宏明; 戸島 洋貴; 柿崎 暁; 植原 大介; 浦岡 俊夫; 滝澤 大地; 畑中 健; 金山 雄樹; 長嶋 茂雄; 長沼 篤; 須賀 孝慶; 高木 均; 高橋 雅春; 高草木 智史
Source
肝臓 / Kanzo. 2020, 61(9):478
Subject
Language
Japanese
ISSN
0451-4203
1881-3593
1881-3593
Abstract
In 2019, the number of reported cases of hepatitis E in Gunma prefecture was 1.44 per 100,000 people, which was the highest in all of Japan. We examined the clinical characteristics of 20 cases of hepatitis E reported in 2019 and analyzed the hepatitis E virus (HEV) genomes of seven sporadic cases. All HEV strains isolated from these cases belonged to subgenotype 3a and were 99.7% to 100% identical to each other within the 412-nucleotide ORF2 sequences. Of these seven cases, six had eaten raw or undercooked pig liver/intestine within the past three months, suggesting that they had been infected with a swine-derived HEV strain. When a small epidemic is suspected, HEV genome analysis should be performed to identify the cause of infection, even in sporadic cases.