부산대학교 도서관

As in the general population, peripheral artery disease (PAD) is reported to be closely associated with the onset of coronary artery disease (CAD) or stroke in hemodialysis patients. PAD has been suggested to be a strong prognostic factor of all-cause and CAD-related deaths in this population. We performed exploratory investigation of the factors associated with new-onset PAD in non-diabetic patients on hemodialysis. In our retrospective cohort study to explore the factors related to new-onset PAD, 106 non-diabetic outpatients undergoing maintenance hemodialysis with no signs of PAD at baseline (as confirmed by duplex ultrasonography examination of the lower extremity arteries) at a single dialysis unit were enrolled. Follow-up duplex ultrasonography examination of the lower extremity arteries was performed five years later to assess the presence or absence of PAD. Multivariate logistic regression analyses were employed to investigate which of the following covariates are associated with new-onset PAD: age, sex, smoking habit, hypo- High Dense Lipoprotein (HDL) cholesterolemia, and statin use. Findings on multivariate logistic regression analyses, with adjustments for potential confounding variables, demonstrated a significant relation between hypo-HDL cholesterolemia and new-onset PAD (odds ratio 1.91, 95%CI 1.11-3.34, p＝0.02). The present study suggested a possible association between hypo-HDL cholesterolemia and new-onset PAD in patients on hemodialysis.