학술논문
Comparative Study of Cefuzonam (CZON) with Cefmenoxime in Chronic Respiratory Tract Infections by Double Blind Method / 慢性呼吸器感染症に対するCefuzonam (CZON) とCefmenoxime (CMX) の薬効比較試験
Document Type
Journal Article
Author
Akihito MURATA; Akimitsu KAMITSUNA; Akio AOYAGI; Akio HIRAYAMA; Akira ITO; Akira SAITO; Akira SAKAMOTO; Akira WATANABE; Atsushi SAITO; Atsushi SHINODA; Chiharu KUBO; Eiji CHIKATA; Eiji INOUE; Einosuke UEDA; Eiro TSUBURA; Fujio TANAKA; Fumio ARIJI; Fumio MATSUMOTO; Fumio MIKI; Fumishige SONODA; Fumitoshi YAMAUCHI; Fumiyuki KUZE; Fusanosuke YAMASAKU; Fuyuhiko HIGASHI; Hideaki KUROKI; Hidekazu HANAKI; Hideki NISHIKAWA; Hideki NISHIYAMA; Hideo IKEMOTO; Hideo SASAKI; Hideo TAKAHASHI; Hidetsugu KAMIYAMA; Hiroaki TAKEDA; Hirofumi FUKUHARA; Hiroichi TANIMOTO; Hiroko KAWAMURA; Hiroko SUGI; Hiromichi HORIKAWA; Hiroshi KAWANE; Hiroshi NAKANO; Hiroshi OKUBO; Hiroshi TOMITA; Hiroyuki KOBAYASHI; Hirozumi SAKAI; Hitoshi IWATA; Hitoshi KOBAYASHI; Ichiro NAKAYAMA; Ippei FUJIMORI; Izumi HAYASHI; Jiro HINO; Jun GOTO; Jun NAGANO; Junzaburo KABE; Kaitaro YAMABE; Kazuhiko TERAKAWA; Kazuhiro OKUNO; Kazuko YOSHIDA; Kazumichi MIYA; Kazumine KOBORI; Kazunori SHIMOGUCHI; Kazuo ITASAKA; Kazuo SAKAMOTO; Kazuo SASAYAMA; Kazuyoshi WATANABE; Keiji KOBAYASHI; Keimei MASHIMO; Keizo MATSUMOTO; Keizo YAMAGUCHI; Kenichi TAKAHASHI; Kenichi YAMAKI; Kenji BABA; Kenzo SHIODA; Kenzo TAKAGI; Kikuo ONUMA; Kinichi IZUMIKAWA; Kiyomichi YOSHIMARU; Kiyoshi KONNO; Kohei HARA; Koichi FUKUYAMA; Koichi WADA; Koichi WATANABE; Koichiro KUDO; Koichiro NAKATA; Kojiro YASUNAGA; Kosaku NAGAI; Kota KONO; Kotaro OIZUMI; Kunihiko YOSHIMURA; Kyoko YAMASHITA; Makio KURIHARA; Makoto TAKAHASHI; Masaaki ARAKAWA; Masahiro TAKAMOTO; Masahito KATO; Masakazu TAMURA; Masanaga TAKATO; Masao NAKATOMI; Masao TANO; Masaru NAKAGAWA; Masaru NASU; Masaru SUMI; Masashi KAWAHARA; Masashi TAMURA; Masataka KATSU; Masatoshi IMAI; Masatoshi WATANABE; Masayasu KAWANISHI; Masayuki ANDO; Masayuki ITO; Masumi TOMIZAWA; Michiro YAMAKIDO; Minoru NISHIMIYA; Mitsuo OBANA; Mitsuo YAMAGISHI; Moritaka SUGA; Morito IWANAGA; Motohide SASAMOTO; Motokazu KATO; Naohiko CHONABAYASHI; Naotsugu KURIHARA; Nobuki AOKI; Osamu KURIMURA; Osamu SEKINE; Rinzo SOEJIMA; Ryujiro SUZUKI; Seibun YONEZU; Shigeki ODAGIRI; Shigeki YOKOYAMA; Shigenobu UMEKI; Shinichi OKA; Shinichi TANIZAWA; Shinji OKUI; Shinya YASUDA; Shiro IDA; Soichiro UEHARA; Syukuro ARAKI; Tadahiro KURASAWA; Tadanao TAKEDA; Tadao ISE; Tadashi MIYAHARA; Takakazu KIYA; Takako MURAYAMA; Takao OKUBO; Takashi INAMATSU; Takashi ITO; Takashi YOKOSE; Takayoshi TASHIRO; Tamotsu TAKISHIMA; Tatsuo NAKATANI; Tatsuo SATAKE; Teiichi KATO; Teruo HASUIKE; Tetsuji KORAKU; Tetsuzo WATANABE; Tomiji MIURA; Tomoyasu SASAKI; Toshiaki HAYASHI; Toshiaki YOSHIDA; Toshifumi NIIBORI; Toshiharu MATSUSHIMA; Toshihiko TAKEUCHI; Toshinori KAWASAKI; Toshio KISHIMOTO; Tsuguji ITO; Tsuneo ISHIBASHI; Tsunetoshi KOTEDA; Yasuhiro HASEGAWA; Yasuko HARADA; Yasuko OJIRO; Yasushi UEDA; Yasutoshi SUZUKI; Yasuyuki SANO; Yoichi FUKUDA; Yoichiro GOTO; Yoji SUZUYAMA; Yoji USAMI; Yoshihiko SAKAKIBARA; Yoshihiro UEDA; Yoshihisa NAKAGAWA; Yoshihito NIKI; Yoshikatsu NEMOTO; Yoshimitsu HAYASHI; Yoshinao IHARA; Yoshio KOBAYASHI; Yoshio YAMADA; Yoshiro SAWAE; Yoshitaka NAKAMORI; Yoshiteru SHIGENO; Yoshiyasu IKUNO; Yube IIDA; Yuji NAKAI; Yukio KUMAGAI; Yukio NISHIMOTO; Yuriko OKAMOTO; Yuzo FUNATSU; 三木 文雄; 三浦 富次; 上原 総一郎; 上山 秀嗣; 上田 泰; 上田 良弘; 上田 英之助; 上綱 昭光; 下口 和矩; 中井 祐之; 中富 昌夫; 中山 一朗; 中川 勝; 中川 義久; 中森 祥隆; 中浜 力; 中田 紘一郎; 中谷 龍王; 中野 博; 久世 文幸; 久保 千春; 二木 芳人; 井上 英二; 井原 義尚; 井田 士朗; 今井 昌利; 今野 淳; 伊勢 忠男; 伊藤 亜司; 伊藤 正幸; 伊藤 章; 伊藤 隆司; 佐々木 智康; 佐々木 英夫; 佐竹 辰夫; 佐野 靖之; 倉沢 忠弘; 副島 林造; 加藤 元一; 加藤 政仁; 加藤 錠一; 勝 正孝; 原 耕平; 原田 泰子; 可部 順三郎; 吉丸 清道; 吉村 邦彦; 吉田 俊昭; 吉田 和子; 和田 光一; 坂本 一夫; 坂本 翊; 堀川 博通; 塩田 憲三; 大久保 滉; 大久保 隆男; 大沼 菊夫; 大泉 耕太郎; 奥井 津二; 奥野 一裕; 宇佐美 郁治; 安永 幸二郎; 安田 也; 安藤 正幸; 宮 一路; 宮原 正; 富澤 磨須美; 富田 弘志; 寺川 和彦; 小代 恭子; 小六 哲司; 小張 一峰; 小林 仁; 小林 宏行; 小林 敬司; 小林 芳夫; 小田切 繁樹; 小花 光夫; 山下 京子; 山作 房之輔; 山内 文俊; 山口 恵三; 山岸 光夫; 山木 健市; 山木戸 道郎; 山田 義夫; 山部 快太郎; 岡 慎一; 岡本 緩子; 岩永 守登; 岩田 仁; 岸本 寿男; 川原 正士; 川崎 紀則; 川村 治子; 川根 博司; 川西 正泰; 工藤 宏一郎; 平山 亮夫; 後藤 純; 後藤 陽一郎; 斎藤 厚; 斎藤 玲; 斎藤 篤; 新堀 俊文; 日野 二郎; 智片 英治; 有路 文雄; 木谷 崇和; 杉 裕子; 村山 尚子; 村田 哲人; 東 冬彦; 松島 敏春; 松本 慶蔵; 松本 文夫; 板阪 和雄; 林 嘉光; 林 敏明; 林 泉; 栗原 収夫; 栗原 直嗣; 栗村 統; 根本 義勝; 梅木 茂宣; 榊原 嘉彦; 横山 繁樹; 横瀬 節; 武内 俊彦; 武田 博明; 武田 忠直; 池本 秀雄; 河野 浩太; 泉川 欣一; 渡辺 一功; 渡辺 哲三; 渡辺 彰; 渡辺 正俊; 渡辺 講一; 滝島 任; 澤江 義郎; 熊谷 幸雄; 生野 善康; 田中 不二穂; 田代 隆良; 田村 昌士; 田村 正和; 田野 正夫; 真下 啓明; 石橋 凡雄; 福原 弘文; 福山 興一; 福田 陽一; 稲松 孝思; 笹山 一夫; 笹本 基秀; 篠田 厚; 籠手田 恒敏; 米津 精文; 船津 雄三; 花木 英和; 苑田 文成; 荒川 正昭; 荒木 淑郎; 菅 守隆; 蓮池 照夫; 藤森 一平; 蝶名林 直彦; 螺良 英郎; 西宮 実; 西山 秀樹; 西川 秀樹; 西本 幸男; 角 優; 谷本 普一; 谷澤 伸一; 那須 勝; 酒井 宏純; 重野 芳輝; 鈴山 洋司; 鈴木 康稔; 鈴木 隆二郎; 長井 弘策; 長谷川 泰弘; 長野 準; 関根 理; 青木 信樹; 青柳 昭雄; 飯田 夕; 馬場 健児; 高木 健三; 高本 正祇; 高橋 健一; 高橋 英男; 高橋 誠; 高頭 正長; 黒木 秀明
Source
感染症学雑誌 / Kansenshogaku Zasshi. 1986, 60(8):865
Subject
Language
Japanese
ISSN
0387-5911
1884-569X
1884-569X
Abstract
A double blind comparative study was conducted to objectively evaluate the clinical efficacy and safety of Cefuzonam (CZON) in the treatment of chronic respiratory infections. Cefmenoxime (CMX) was used as a control drug. Each drug was administered by intravenous drip infusion 1g at a time, twice daily, for 14 days as a rule.The results were as follows:1. Treated in this study were 167 cases in total, 88 of CZON group and 79 of CMX group, but subjected for clinical evaluation by the evaluation committee were 147 cases, 77 of CZON group and 70 of CMX group, with 20 cases (11 of CZON group and 9 of CMX group) excluded from the committee's evaluation.2. Clinical effectiveness assessed by the committee showed the efficacy rates of 81.8%(63 cases our of 77) for CZON group and 80.0%(56 cases out of 70) for CMX group, with no significant difference observed between the two drug groups. Also, there was no significant difference between the two groups in clinical efficacy evaluation by physicians in charge.3. Classified by causal bacteria, clinical efficacy rates were 85.2% for CZON group and 78.6% for CMX group, and in single infection cases of gram-positive bacteria the effectiveness rates were 100% for CZON group and 75.0% for CMX group. In these two evaluations, CZON group showed higher efficacy percentages but no statistically significant difference was observed between the two drug groups. As for bacterial eradication rate, CZON group showed higher percentage but no significant difference was noted.4. The incidence rate of abnormality in laboratory tests was lower for CZON than for CMX, but no significant difference was observed. Side effects incidence rates showed no significant difference between the two groups.5. Usefulness rates by the evaluation of the committee were 77.9%(60 cases out of 77) for CZON group and 77.1%(54 cases out of 70) for CMX group, whereas evaluation by physicians in charge were 71.1%(54 cases out of 76) for CZON group and 82.6%(57 cases out of 69) for CMX group. In either evaluation, there was no significant difference observed between the two drug groups.These results show that CZON is a useful drug in the treatment of chronic respiratory infections.