부산대학교 도서관

Mice were subcutaneously inoculated with a mouse cancer cell line. They were allocated into the control，anti-PD-L1 antibody, low molecular weight compound and their combination treatment groups. Anti-PD-L1 antibody was administered intraperitoneally twice a week for two weeks. The low molecular weight compound was administered orally once a day for 14 days. The tumor diameters were measured to calculate the tumor volumes. Observation and measurement were performed for 14 days after the initiation of administration. The tumor was excised and dispersed to analyze tumor-infiltrating lymphocytes（TILs）. The dispersed cells were stained with fluorescent-labeled antibodies and analyzed using the flow cytometer.