부산대학교 도서관

A 68-year-old woman was referred to our hospital in October 2011 for an umbilical nodule that had appeared 2 months earlier. A skin biopsy specimen taken from the lesion histologically showed atypical squamous cell invasion from the epidermis into the dermis, suggesting cutaneous squamous cell carcinoma. Magnetic resonance imaging (MRI) was performed before treatment, and revealed that she had a smooth tumor, approximately 10.5×13.5×17 centimeters at her right ovary. At that time, we diagnosed her as having a cutaneous squamous cell carcinoma and a benign ovarian tumor. However, during the operation, the ovarian tumor was diagnosed as being histologically malignant. Thus, the patient underwent wide-excision. Finally, we diagnosed this case as being a Sister Mary Joseph's nodule associated with mature cystic ovarian teratoma. She underwent additional chemotherapy combined with Paclitaxel and Carboplatin. During the follow up over the 18 subsequent months, there was no evidence of disease recurrence or metastasis. Although malignant transformation of a mature cystic ovarian teratoma is very rare, in such a case the tumor occasionally presents as a squamous cell carcinoma. Thus, a Sister Mary Joseph's nodule originating from mature cystic ovarian teratoma is indistinguishable from cutaneous squamous cell carcinoma. This article reports important information for dermatologists.[Skin Cancer (Japan) 2013 ; 28 : 34-38]