부산대학교 도서관

Bronchial sensitivity and reactivity in 57 patients with bronchial asthma was measured using Astographs and transcutaneous oxygen tension (PtcO2) during continuous inhalation of methacholine at incremental concentrations.Bronchial sensitivity and reactivity could be determined by these 2 methods in 42 of the 57 patients.The correlation between the minimum dose of methacholine, which was defined as the indicator for bronchial sensitivity, in the Astograph and in PtcO2 was significantly high (n=42, r=0.89, p<0.001).The correlation between the slope of increasing rate of respiratory resistance and that of decreasing rate of PtcO2, which indicated bronchial reactivity, was significantly high (n=42, r=0.85, p<0.001).Although it was difficult to obtain reliable Astographs in some of the young children because of their marked changes in respiratory resistance, the measurement of PtcO2 was found to be effective for the evaluation of bronchial sensitivity and reactivity in these cases.