부산대학교 도서관

The effect of pantethine treatment on serum lipids, lipoproteins and on the activity of plasma lipoprotein lipase (LPL) and hepatic triglyceride lipase (H-TGL) has been studied in 8 healthy males. An increase was observed in the LPL activity and in the serum concentration of high density lipoprotein (HDL) cholesterol, in particular in HDL2, after 4 weeks of treatment.In rat experiments, an increase was observed in the activity of not only LPL but H-TGL after pantethine treatment. LPL extracted from control and pantethine-treated rat adipose tissue acetone-ether powders, was separated by heparin-Sepharose affinity chromatography into two active fractions. In pantethine-treated group, the first peak, named LPL “1” originated from the micro somal fraction, had clearly increased while the second one, LPL “2” originated from the plasma membrane, had remained virtually unchanged.These results suggest that the synthesis of LPL protein in adipose tissue and the activity of this enzyme are activated by the administration of pantethine, followed by increase of HDL, particularly HDL2.