학술논문

Studies on β-Lactam Antibiotics for Medicinal Purpose. VIII. Synthesis of 7-[D(-)-α-(4-Alkyl-2, 3-dioxo-1-piperazinecarboxamido) phenylacetamido]-cephalosporanic Acids and Structure-Antibacterial Activity / β-ラクタム系抗生物質の薬学的研究(第8報)7-[D(-)-α-(4-Alkyl-2,3-dioxo-1-piperazinecarboxamido)phenylacetamido]cephalosporanic Acid類の合成ならびに構造-抗菌活性

Document Type

Journal Article

Author

CHIAKI KUTANI; CHOSAKU YOSHIDA; HIDEO TAKI; HIROKAZU OCHIAI; ISAMU SAIKAWA; ISAMU TAKAKURA; KAISHU MOMONOI; SHUNTARO TAKANO; TAKASHI YASUDA; 保田隆; 吉田長作; 工谷千秋; 才川勇; 桃井海秀; 滝秀雄; 落合裕一; 高倉勇; 高野俊太郎

Source

YAKUGAKU ZASSHI. 1979, 99(9):929

Subject

7-[D(-)-α-(4-alkyl-2, 3-dioxo-1-piperazinecarboxamido) phenylacetamido] cephalosporanic acids
D(-)-α-(4-alkyl-2, 3-dioxo-1-piperazinecarboxamido)phenylacetic acid
MIC
antibiotics
semisynthetic cephalosporins
structure-antibacterial activity

Language

Japanese

ISSN

0031-6903
1347-5231

Abstract

7-[D(-)-α-(4-Alkyl-2, 3-dioxo-1-piperazinecarboxamido) phenylacetamido]-3-substituted methyl-3-cephem-4-carboxylic acids (I) were prepared. In vitro antibacterial activity against S. aureus, E. coli, Ps. aeruginosa, P. vulgaris and K. pneumoniae was tested and it was found to have a strong antibacterial activity against gram-negative bacilli, especially to Ps. aeruginosa and P. vulgaris.

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