학술논문

Studies on β-Lactam Antibiotics for Medicinal Purpose. V. Structure of Degradation Products of 6-[D (-)-α-(4-Ethyl-2, 3-dioxo-1-piperazinecarboxamido) phenylacetamido] penicillanic Acid (T-1220) in Aqueous Solution / β-ラクタム系抗生物質の薬学的研究(第5報)6-[D(-)-α-(4-Ethyl-2,3-dioxo-1-piperazinecarboxamido)phenylacetamido]penicillanic Acid(T-1220)の水溶液中分解物の構造

Document Type

Journal Article

Author

CHOSAKU YOSHIDA; HIROSHI SAKAI; ISAMU SAIKAWA; MASARU TAI; SHUNTARO TAKANO; TAKASHI YASUDA; YOSHIKO YAMAMOTO; 保田隆; 吉田長作; 山本芳子; 才川勇; 田井賢; 酒井広志; 高野俊太郎

Source

YAKUGAKU ZASSHI. 1977, 97(10):1064

Subject

6-[D (-)-α-(4-ethyl-2, 3-dioxo-1-piperazinecarboxamido) phenylacetamido] penicillanic acid (T-1220)
antibiotics
identification of structure
α-(4-ethyl-2, 3-dioxo-1-piperazinecarboxamido) benzylpenicilloic acid
α-(4-ethyl-2, 3-dioxo-1-piperazinecarboxamido) benzylpenilloic acid
α-{3-[2-(N-ethyl-N-oxaloamino) ethyl] ureido} benzylpenicillin
α-{3-[2-(N-ethyl-N-oxaloamino) ethyl] ureido} benzylpenicilloic acid

Language

Japanese

ISSN

0031-6903
1347-5231

Abstract

The structure of degradation compounds of T-1220 in aqueous solution was investigated. It was confirmed that in alkaline solution, α-{3-[2-(N-ethyl-N-oxaloamino) ethyl]-ureido} benzylpenicillin (T-1220 A), α-(4-ethyl-2, 3-dioxo-1-piperazinecarboxamido) benzylpenicilloic acid (T-1220B) and α-{3-[2-(N-ethyl-N-oxaloamino) ethyl] ureido} benzylpenicilloic acid (T-1220 C) were produced, and that in acid solution, T-1220 B and α-(4-ethyl-2, 3-dioxo-1-piperazinecarboxamido) benzylpenilloic acid (T-1220 D) wera produced.

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