학술논문
A clinical evaluation of temafloxacin in otorhinolaryngological infection involoving the otitis media and the otitis externa / 耳鼻咽喉科領域感染症に対するTemafloxacinの臨床評価
Document Type
Journal Article
Author
Akihiro UCHIZONO; Akira YOKOTA; Atsuko ETO; Atsushi SAMEJIMA; Atsushi SHINKAWA; Ginichiro ICHIKAWA; Goro MOGI; Haruo ITO; Hideaki TAKAHASHI; Hideshige KIMURA; Hideyo ASAI; Hideyuki UCHI; Hiroko ISAJI; Hiromi ITO; Hiromi YANO; Hirosato MIYAKE; Hiroshi TSURUMARU; Hiroshi WATANABE; Humiko IIDA; Ichiro MORIYAMA; Junichiro SHIMADA; Katsuhiro HIRAKAWA; Keiko NISHIKAWA; Ken KITAMURA; Koichi KITA; Koji AJISAKA; Koji SERA; Makoto SHIRANE; Mamoru SUZUKI; Masahiko EGAWA; Masahiro MIZUNO; Masakaze NAKATA; Masaru OYAMA; Masashi WADA; Masayoshi OZAKI; Masutoshi NISHIKAWA; Minoru ISHIDA; Nagahiro SO; Naoya MIYAMOTO; Noritsugu KANEDA; Ryo OMURA; Shigeru KIKUCHI; Shinjiro ONISHI; Shinya MATSUNAGA; Shozo KAWAMURA; Shuji SATO; Shunkichi BABA; Sinichiro YAMAMOTO; Soichiro NAGATA; Soiku WATANABE; Taeko OKUNO; Takatsugu ITABASHI; Takehiro KOBAYASHI; Tamotsu HARADA; Tatsuya OKUZONO; Tatsuya YAMASOBA; Tetsuhiko INOKUMA; Tetsuya SHIMA; Tetsuyasu HIRATA; Toru MATSUNAGA; Toru SEKITANI; Toshikazu SASAKI; Yasuhiko TAHARA; Yasuhiro MIYAZAKI; Yasuo HARADA; Yasuya NOMURA; Yoriko ITO; Yoshiko OKUZONO; Yutaka SAKAMOTO; 三宅 浩郷; 世良 公志; 中田 將風; 伊佐治 広子; 伊藤 依子; 伊藤 弘美; 伊藤 晴夫; 佐々木 俊一; 佐藤 修治; 内 秀之; 内薗 明裕; 原田 保; 原田 康夫; 和田 昌士; 喜多村 健; 坂本 裕; 大山 勝; 大西 信治郎; 奥園 美子; 奥園 達也; 奥野 妙子; 宗 永浩; 宮崎 康博; 宮本 直哉; 小村 良; 小林 武弘; 尾崎 正義; 山岨 達也; 山本 真一郎; 島 哲也; 島田 純一郎; 市川 銀一郎; 平川 勝洋; 平田 哲康; 新川 敦; 木村 栄成; 松永 亨; 松永 信也; 板橋 隆嗣; 森山 一郎; 横田 明; 水野 正浩; 永田 総一郎; 江川 雅彦; 江渡 篤子; 河村 正三; 浅井 英世; 渡辺 洋; 渡辺 荘郁; 猪熊 哲彦; 田原 康彦; 白根 誠; 矢野 博美; 石田 稔; 紀太 康一; 茂木 五郎; 菊地 茂; 西川 恵子; 西川 益利; 野村 恭也; 金田 規嗣; 鈴木 衛; 関谷 透; 飯田 冨美子; 馬場 駿吉; 高橋 秀明; 鮫島 篤史; 鰺坂 孝二; 鶴丸 浩士
Source
耳鼻と臨床 / jibi to rinsho. 1994, 40(2):182
Subject
Language
Japanese
ISSN
0447-7227
2185-1034
2185-1034
Abstract
Temafloxacin(TMFX) was evaluated for its efficacy, safety, usefulness as well as for its penetration into the otorrhea. Regarding its efficacy as evaluated by the doctor in charge, the efficacy rates were 72.9% in the otitis media, 87.5% in the otitis externa, and 100% for infection of congenital aural fistula. Regarding its efficacy as evaluated by the committee in charge, the efficacy rate was 66.1% in the otitis media. The bacteriological eradication rates were 84.6% for gram-positive bacteria, 66.7% for gram-negative bacteria and 81.1% for all bacteria. Side effects were observed in 2(one had rush, while the other had glossal rough) of 159 cases while abnormal clinical laboratory findings occured in 2(consisting of an increase in GOT and GPT) of 66 cases. The rates of usefulness were 72.0% in the otitis media, 87.5% in the otitis externa, 100% for infection of congenital aural fistula. The concentration of TMFX was 1.29μg/ml in the otorrhea, based on the findings of only one case. From these results, TMFX is thus considered to be useful for otorhinolaryngological infections in the otitis media, and otitis externa as for infection of the congenital aural fistula.