부산대학교 도서관

Malignant rhabdoid tumor of the kidney (MRTK) in infants often shows poor prognosis. Here, we report a fatal case of an infant with MRTK that was refractory to multidisciplinary treatment. An eight-month-old male infant initially presented with an abdominal mass and gross hematuria. Computed tomography revealed a mass 75 mm in diameter in the right kidney without metastasis. He was tentatively diagnosed as having stage I right renal tumor and underwent one-stage surgical resection followed by postoperative chemotherapy. However, postoperative histopathological findings confirmed MRTK with renal capsule invasion. Despite receiving focal abdominal irradiation and three courses of chemotherapy comprising vincristine, doxorubicin, and cyclophosphamide, the patient developed peritoneal metastasis and died on day 130. MRTK shows rapid progression with a fatal outcome, mainly in infants. Development of novel therapeutic agents based on the pathology and biology of MRTK is warranted to improve the treatment outcome of MRTK.