학술논문
Massive perivillous fibrin depositionを呈したRhD不適合妊娠における病理学的検討 / Massive perivillous fibrin deposition in a pregnancy with rhesus D incompatibility: A case report
Document Type
Journal Article
Author
Source
日本周産期・新生児医学会雑誌 / Journal of Japan Society of Perinatal and Neonatal Medicine. 2023, 59(2):245
Subject
Language
Japanese
ISSN
1348-964X
2435-4996
2435-4996
Abstract
She was managed in the neonatal intensive care unit and discharged at the age of 170 days. The placenta showed white infarcts grossly and extensive fibrin deposition around the chorionic villi histopathologically. Therefore a diagnosis of MPVFD was made. In this case, immunohistochemistry showed IgG and alkaline phosphatase（ALP）expression in the villi near the fibrin. We suspected the involvement of the IgG-ALP complex, known to be found in placental villi of RhD-incompatible pregnancies, in the development of MPVFD. Herein, we report a case of MPVFD in an RhD-incompatible pregnancy, including a literature review.