부산대학교 도서관

The influence of the physicochemical properties of fatty suppository bases on the vaginal absorption of prasterone sulfate (PS) was investigated. The suppository bases tested were Witepsol® H-15, H-35 and W-35, and the vaginal absorption of PS from these suppositories was studied using rats. The area under the plasma concentration-time curve (AUC) of PS obtained with H-15 suppository was higher than that observed using H-35 or W-35 suppository. No differences in the viscosity of suppository, PS permeability through vaginal membrane or the release of PS were detected among H-15, H-35 and W-35 suppositories. The spreading of base and drug of the H-15 suppository was superior to that of the H-35 or W-35 suppository. These results indicate that Witepsol® H-15 is an appropriate base for the preparation of PS vaginal suppositories.